The Brit is looking to seal a place in the quarter finals at Flushing Meadows for a sixth time when he battles the 6ft8 South African, with the winner going on to meet either Stan Wawrinka or Donald Young.
After a testy start to the tournament, Murray made easy work of 30th seed Thomaz Bellucci in round three, winning in straight sets for the first time in the tournament despite suffering with a cold- interesting given the humid conditions in New York.
The third seed will now move on to face his biggest test in the tournament so far in the big serving Anderson who he holds a 5-1 head to head record against.
The 14th seed is in a rich vein of form after winning in Winston Salem prior to the US Open, and he has continued that form in to New York. Anderson dispatched Austrian youngster Dominic Thiem in the third round 6-3, 7-6(5), 7-6(5).
The South African’s form has seen him achieve a career high ranking of 14 and top the aces chart so far in the tournament with 69- impressive given that John Isner is also still in the tournament.
Anderson is through to his first ever round four at the US Open, completing the career round four grand slam if you will. But the 29 year old has never made it to the quarter finals at the biggest stage. He did come close at Wimbledon when he went two sets up against Novak Djokovic, but ultimately he was defeated in five.
But all eyes will be on court when the world number three faces the world number 14 for a place in the last eight.
Murray will play 14th seed Kevin Anderson on Louis Armstrong Stadium at around 20:00 BST. You can follow his progress via the Britwatch Live Scores
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